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Leukocyte esterase

Definition

Leukocyte esterase is a urine test to look for white blood cells and other signs associated with infection.

Alternative Names

WBC esterase

How the Test is Performed

A clean catch urine sample is needed. See: Urine specimen - clean catch

How to Prepare for the Test

No special preparation is necessary for this test.

How the Test Will Feel

The test will involve only normal urination, and there is no discomfort.

Why the Test is Performed

Leukocyte esterase is a screening test used to detect a substance that suggests there are white blood cells in the urine, which may mean you have a urinary tract infection.

This test is part of the routine urine dipstick test. If this test is positive, the urine should be examined under a microscope for white blood cells and other abnormalities associated with infection.

Normal Results

A negative test result is normal.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What Abnormal Results Mean

An abnormal result indicates a possible urinary tract infection.

Risks

There are no risks.

Considerations

The following may create a false positive result:

  • Vaginal secretions (such as blood or heavy mucus discharge)
  • Trichomonas infection (such as trichomoniasis)

False negative tests can be caused by:

  • High levels of protein
  • High levels of vitamin C
Review Date: 1/10/2010
Reviewed By: David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and Louis S. Liou, MD, PhD, Assistant Professor of Urology, Department of Surgery, Boston University School of Medicine.
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